Chronic wounds such as diabetic or venous ulcers can present a clinical challenge with prolonged inflammation, increased infections risk, and limited capabilities for tissue regeneration. These wounds fail to progress appropriately through the 4 stages of wound healing (hemostasis, inflammation, proliferation, and maturation) and usually require advanced approaches to help support tissue integrity. Amniotic membrane grafts have emerged as an innovative option within the advanced wound care space. Upon application, the graft serves as a protective covering that helps maintain a moist, breathable wound environment, while also assisting in reducing discomfort and minimizing fluid loss from the affected tissue.